Zuikeiin was the principle wife of Houjou Ujiyasu. They married in 1538, and she bore him his son and heir Houjou Ujimasa, as well as Houjou Ujikuni, Houjou Ujinori, Houjou Ujiteru, and Houjou Saburou (Uesugi Kagetora), though these last two are in debate. She was the daughter of Imagawa Ujichika and sister of Imagawa Yoshimoto.