Also known as: Nagao Kagenobu (長尾景信), Koshin no Juurou (古志の十郎), Uesugi Juurou Kagenobu (上杉十郎景信)

Uesugi Kagenobu was the son of Nagao Fusakage of the Echigo-Nagao Clan and was the head of the Koshin-Nagao family. He raised the standard of revolt against the Uesugi Clan around the late 1520s or early 1530s, which was around when he succeeded his father as head of the family.

When Nagao Kagetora (Uesugi Kenshin) came into power, he became Kenshin's vassal along with others such as Nagao Masakage and Sanbonji Sadanaga. In 1561, when Kenshin became Kantou Kanrei and took the Uesugi name, Kagenobu also changed his surname to Uesugi. He participated in Kenshin's wars of subjugation of the Kantou and against the Takeda Clan.

There were a few skirmishes and some antagonism between himself and Nagao Masakage/his son Uesugi Kagekatsu of the Ueda-Nagao family, who had the same level of authority within the clan, so in the Otate no Ran after Kenshin's death, he supported Uesugi Kagetora. He died in battle against Murakami Kunikiyo on July 15th.